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Summary ExpressionExpr. PhenotypesPheno. Gene Literature (27)Lit. (27) GO Terms (111)GO (111) Nucleotides (243)Nucl. (243) Proteins (79)Prot. (79) Interactants (322)Interact. (322) Wiki
XB-GENEPAGE-482710
???displayGene.symbol???:
 mdm2

???displayGene.name???: 
MDM2 proto-oncogene

???displayGene.synonyms???
double minute-2 , LOC108713153 , xdm-2 , Xdm2 ( Nomenclature history )

???displayGene.geneFunction???
E3 ubiquitin ligase

AI Protein Function :
mdm2 is an E3 ubiquitin‑protein ligase that ubiquitinates p53 and promotes its proteasomal degradation, thereby limiting p53‑mediated transcription of pro‑apoptotic genes and regulating cell‑cycle prog...[+]


InterPro :
Znf RING, Mdm2, Znf RanBP2, SWIB MDM2 dom sf, [+]

???displayGene.geneInteractants???
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Diseases: 


MIM:
ACCELERATED TUMOR FORMATION, SUSCEPTIBILITY TO; ACTFS

External Links:
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???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


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