Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary ExpressionExpr. PhenotypesPheno. Gene Literature (62)Lit. (62) GO Terms (58)GO (58) Nucleotides (169)Nucl. (169) Proteins (52)Prot. (52) Interactants (194)Interact. (194) Wiki
XB-GENEPAGE-990636
???displayGene.symbol???:
 topbp1

???displayGene.name???: 
DNA topoisomerase II binding protein 1

???displayGene.synonyms???
cut5 , mus101 , top2bp1 , Xmus101 ( Nomenclature history )

???displayGene.geneFunction???
Nucleotide excision repair factor NEF2, RAD4/CUT5 component

AI Protein Function :
topbp1 is a nuclear scaffold protein that participates in DNA replication initiation, promotes origin firing, stabilizes replication forks, and acts as a key mediator of DNA damage checkpoint signaling...[+]


InterPro :
BRCT dom, BRCT dom sf, BRCT TopBP1 rpt8, TopBP1-like BRCT0, [+]

???displayGene.geneInteractants???
Loading ...

Diseases: 


External Links:
Loading gene data...
Please wait while we fetch the latest information
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info