Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary ExpressionExpr. PhenotypesPheno. Gene Literature (11)Lit. (11) GO Terms (233)GO (233) Nucleotides (147)Nucl. (147) Proteins (52)Prot. (52) Interactants (224)Interact. (224) Wiki
XB-GENEPAGE-989002
???displayGene.symbol???:
 sirt1

???displayGene.name???: 
sirtuin 1

???displayGene.synonyms???
sir2l1 , sirtuin , xsirt1 ( Nomenclature history )

???displayGene.geneFunction???
Sirtuin 5 and related class III sirtuins (SIR2 family)

AI Protein Function :
sirt1 is a NAD‑dependent deacetylase that modulates chromatin and transcriptional regulators, influencing metabolic and stress pathways. It localizes to the nucleus and can translocate to the cytoplasm...[+]


InterPro :
DHS-like NAD/FAD-binding dom, Sirtuin cat small dom sf, Sirtuin, Ssirtuin cat dom, [+]

???displayGene.geneInteractants???
Loading ...

Diseases: 


External Links:
Loading gene data...
Please wait while we fetch the latest information
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info