Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Expr. PhenotypesPheno. Gene Literature (15)Lit. (15) GO Terms (92)GO (92) Nucleotides (122)Nucl. (122) Proteins (59)Prot. (59) Interactants (152)Interact. (152) Wiki
XB-GENEPAGE-962371
???displayGene.symbol???:
 ldlr

???displayGene.name???: 
low density lipoprotein receptor

???displayGene.synonyms???
fhc , ldlcq2 , ldlr-a , ldlr-b ( Nomenclature history )

???displayGene.geneFunction???
EGF-like calcium ion binding

AI Protein Function :
ldlr is a membrane‑bound receptor that binds low‑density lipoprotein particles and mediates their clathrin‑dependent endocytosis, thereby regulating cellular cholesterol uptake and homeostasis. It loca...[+]


InterPro :
6-blade b-propeller TolB-like, EGF-like Ca-bd dom, EGF-like dom, EGF-type Asp/Asn hydroxyl site, [+]

???displayGene.geneInteractants???
Loading ...

Diseases: 


Disease Ontology:
familial hypercholesterolemia

MIM:
HYPERCHOLESTEROLEMIA, FAMILIAL, 1; FHCL1

External Links:
Loading gene data...
Please wait while we fetch the latest information
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info