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Summary Expression Expr. PhenotypesPheno. Gene Literature (14)Lit. (14) GO Terms (10)GO (10) Nucleotides (205)Nucl. (205) Proteins (68)Prot. (68) Interactants (281)Interact. (281) Wiki
XB-GENEPAGE-486032
???displayGene.symbol???:
 lemd3

???displayGene.name???: 
LEM domain containing 3

???displayGene.synonyms???
man1 , sane , Smad1 antagonistic effector , xman1 ( Nomenclature history )

???displayGene.geneFunction???
TGF-beta/BMP signaling

AI Protein Function :
lemd3 is an inner nuclear membrane protein that negatively regulates BMP signaling during early embryogenesis; it acts as a membrane‑bound modulator of the TGF‑β pathway and influences dorsoventral pat...[+]


InterPro :
LEM dom, Nucleotide-bd a/b plait sf, LEM/LEM-like dom sf, MAN1 winged helix dom, [+]

???displayGene.geneInteractants???
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Diseases: 


Disease Ontology:
melorheostosis [+]

MIM:
BUSCHKE-OLLENDORFF SYNDROME; BOS [+]

External Links:
1/3
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???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


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