Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Although a number of genes that are involved in the establishment of left-right asymmetry have been identified, earlier events in the molecular pathway developing left-right asymmetry remain to be elucidated. Here we present evidence suggesting that the transforming growth factor-beta family member derrière is involved in the development of left-right asymmetry in Xenopus embryos. Ectopic expression of derrière on the right side can fully invert cardiac and visceral left-right orientation and nodal expression, and expression of a dominant-negative form of derrière on the left side can partially randomize the left-right orientation and nodal expression. Moreover, while expression of the dominant-negative derrière does not inhibit the activity of Vg1 directly, it can rescue the altered left-right orientation induced by Vg1. Vg1 can induce derrière in animal cap explants. These results suggest that derrière is involved in earlier molecular pathways developing the left-right asymmetry.
Beddington,
Axis development and early asymmetry in mammals.
1999, Pubmed
Beddington,
Axis development and early asymmetry in mammals.
1999,
Pubmed Brown,
The development of handedness in left/right asymmetry.
1990,
Pubmed Capdevila,
Mechanisms of left-right determination in vertebrates.
2000,
Pubmed
,
Xenbase Danos,
Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus.
1996,
Pubmed
,
Xenbase Harvey,
Links in the left/right axial pathway.
1998,
Pubmed Hawley,
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.
1995,
Pubmed
,
Xenbase Hyatt,
The left-right coordinator: the role of Vg1 in organizing left-right axis formation.
1998,
Pubmed
,
Xenbase Hyatt,
Initiation of vertebrate left-right axis formation by maternal Vg1.
1996,
Pubmed
,
Xenbase Lohr,
Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development.
1997,
Pubmed
,
Xenbase Masuyama,
Identification of two Smad4 proteins in Xenopus. Their common and distinct properties.
1999,
Pubmed
,
Xenbase Meno,
Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.
1999,
Pubmed Meno,
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.
1998,
Pubmed Nascone,
Organizer induction determines left-right asymmetry in Xenopus.
1997,
Pubmed
,
Xenbase Nonaka,
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.
1998,
Pubmed Okada,
Abnormal nodal flow precedes situs inversus in iv and inv mice.
1999,
Pubmed Pagán-Westphal,
The transfer of left-right positional information during chick embryogenesis.
1998,
Pubmed Ramsdell,
Molecular mechanisms of vertebrate left-right development.
1998,
Pubmed
,
Xenbase Rodríguez Esteban,
The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry.
1999,
Pubmed
,
Xenbase Sampath,
Functional differences among Xenopus nodal-related genes in left-right axis determination.
1997,
Pubmed
,
Xenbase Sun,
derrière: a TGF-beta family member required for posterior development in Xenopus.
1999,
Pubmed
,
Xenbase Takeda,
Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis.
1999,
Pubmed Thomsen,
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.
1993,
Pubmed
,
Xenbase Yokouchi,
Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression.
1999,
Pubmed
,
Xenbase Zhu,
Cerberus regulates left-right asymmetry of the embryonic head and heart.
1999,
Pubmed
,
Xenbase
