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J Virol
2006 Feb 01;803:1588-91. doi: 10.1128/JVI.80.3.1588-1591.2006.
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Direct stimulation of translation by the multifunctional herpesvirus ICP27 protein.
Larralde O, Smith RW, Wilkie GS, Malik P, Gray NK, Clements JB.
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Herpes simplex virus type 1 (HSV-1) ICP27 protein is an essential regulator of viral gene expression with roles at various levels of RNA metabolism in the nucleus. Using the tethered function assay, we showed a cytoplasmic activity for ICP27 in directly enhancing mRNA translation in vivo in the absence of other viral factors. The region of ICP27 required for translational stimulation maps to the C terminus. Furthermore, in infected cells, ICP27 is associated with polyribosomes, indicating a function in translation during the lytic cycle.
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