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FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes.
Béguin P, Crambert G, Monnet-Tschudi F, Uldry M, Horisberger JD, Garty H, Geering K.
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Recently, corticosteroid hormone-induced factor (CHIF) and the gamma-subunit, two members of the FXYD family of small proteins, have been identified as regulators of renal Na,K-ATPase. In this study, we have investigated the tissue distribution and the structural and functional properties of FXYD7, another family member which has not yet been characterized. Expressed exclusively in the brain, FXYD7 is a type I membrane protein bearing N-terminal, post-translationally added modifications on threonine residues, most probably O-glycosylations that are important for protein stabilization. Expressed in Xenopus oocytes, FXYD7 can interact with Na,K-ATPase alpha 1-beta 1, alpha 2-beta 1 and alpha 3-beta 1 but not with alpha-beta 2 isozymes, whereas, in brain, it is only associated with alpha 1-beta isozymes. FXYD7 decreases the apparent K(+) affinity of alpha 1-beta 1 and alpha 2-beta 1, but not of alpha 3-beta1 isozymes. These data suggest that FXYD7 is a novel, tissue- and isoform-specific Na,K-ATPase regulator which could play an important role in neuronal excitability.
Arystarkhova,
Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit.
2002, Pubmed
Arystarkhova,
Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit.
2002,
Pubmed Attali,
A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes.
1995,
Pubmed
,
Xenbase Béguin,
CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit.
2001,
Pubmed
,
Xenbase Béguin,
The gamma subunit is a specific component of the Na,K-ATPase and modulates its transport function.
1997,
Pubmed
,
Xenbase Blanco,
Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function.
1998,
Pubmed Crambert,
Transport and pharmacological properties of nine different human Na, K-ATPase isozymes.
2000,
Pubmed
,
Xenbase D'Ambrosio,
Differential role of KIR channel and Na(+)/K(+)-pump in the regulation of extracellular K(+) in rat hippocampus.
2002,
Pubmed Forbush,
Characterization of a new photoaffinity derivative of ouabain: labeling of the large polypeptide and of a proteolipid component of the Na, K-ATPase.
1978,
Pubmed Fu,
E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts.
1997,
Pubmed Geering,
Oligomerization and maturation of Na,K-ATPase: functional interaction of the cytoplasmic NH2 terminus of the beta subunit with the alpha subunit.
1996,
Pubmed
,
Xenbase Geering,
The functional role of beta subunits in oligomeric P-type ATPases.
2001,
Pubmed Hansen,
NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility.
1998,
Pubmed Hasler,
Role of beta-subunit domains in the assembly, stable expression, intracellular routing, and functional properties of Na,K-ATPase.
1998,
Pubmed
,
Xenbase Jaisser,
Modulation of the Na,K-pump function by beta subunit isoforms.
1994,
Pubmed
,
Xenbase Juhaszova,
Na+ pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells.
1997,
Pubmed Lippincott-Schwartz,
Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER.
1989,
Pubmed Meij,
Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit.
2000,
Pubmed Mercer,
Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase.
1993,
Pubmed Minor,
The gamma subunit of the Na,K-ATPase induces cation channel activity.
1998,
Pubmed
,
Xenbase Moorman,
Phospholemman expression induces a hyperpolarization-activated chloride current in Xenopus oocytes.
1992,
Pubmed
,
Xenbase Morrison,
Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes.
1995,
Pubmed
,
Xenbase Navarre,
Purification and complete sequence of a small proteolipid associated with the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae.
1992,
Pubmed Odermatt,
Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase.
1998,
Pubmed Palmer,
Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium.
1991,
Pubmed Pressley,
Phylogenetic conservation of isoform-specific regions within alpha-subunit of Na(+)-K(+)-ATPase.
1992,
Pubmed Pu,
Functional role and immunocytochemical localization of the gamma a and gamma b forms of the Na,K-ATPase gamma subunit.
2001,
Pubmed Ransom,
Activity-dependent extracellular K+ accumulation in rat optic nerve: the role of glial and axonal Na+ pumps.
2000,
Pubmed Rettig,
Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer.
1992,
Pubmed Shi,
Membrane topology and immunolocalization of CHIF in kidney and intestine.
2001,
Pubmed Simmerman,
Phospholamban: protein structure, mechanism of action, and role in cardiac function.
1998,
Pubmed Suessbrich,
The IKs channel: coassembly of IsK (minK) and KvLQT1 proteins.
1999,
Pubmed Sweadner,
The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.
2000,
Pubmed Therien,
Tissue-specific versus isoform-specific differences in cation activation kinetics of the Na,K-ATPase.
1996,
Pubmed Therien,
Tissue-specific distribution and modulatory role of the gamma subunit of the Na,K-ATPase.
1997,
Pubmed Uldry,
Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain.
2001,
Pubmed
,
Xenbase Van den Steen,
Concepts and principles of O-linked glycosylation.
1998,
Pubmed von Heijne,
Topogenic signals in integral membrane proteins.
1988,
Pubmed Walz,
Role of astrocytes in the clearance of excess extracellular potassium.
2000,
Pubmed Yamaguchi,
Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus.
2001,
Pubmed
