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J Cell Biol
2003 Feb 03;1603:291-3. doi: 10.1083/jcb.200301040.
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Dynactin polices two-way organelle traffic.
Dell KR.
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How is the bidirectional motion of organelles controlled? In this issue, Deacon et al. (2003) reveal the unexpected finding that dynactin (previously known to control dynein-based motility) binds to kinesin II and regulates anterograde movement of Xenopus melanosomes. This result suggests that dynactin may be a key player in coordinating vesicle traffic in this system.
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