Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Liu Z, Guo J, Wang Y, Weng Z, Huang B, Yu MK, Zhang X, Yuan P, Zhao H, Chan WY, Jiang X, Chan HC.
???displayArticle.abstract???
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated anion channel capable of conducting both Cl - and HCO 3 - , mutations of which cause cystic fibrosis (CF), a common autosomal recessive disease. Although CF patients are known to have varied degree of developmental problems, the biological role of CFTR in embryonic development remains elusive. Here, we show that CFTR is functionally expressed in mouse ESCs. CFTR -/- mESCs exhibit dramatic defect in mesendoderm differentiation. In addition, CFTR physically interacts with β-catenin, defect of which leads to premature degradation of β-catenin and suppressed activation of β-catenin signaling. Furthermore, knockdown of CFTR retards the early development of Xenopus laevis with impaired mesoderm/endoderm differentiation and β-catenin signaling. Our study reveals a previously undefined role of CFTR in controlling ESC differentiation and early embryonic development via its interaction with β-catenin, and provides novel insights into the understanding of embryonic development.
Anton,
Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells.
2007, Pubmed
Anton,
Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells.
2007,
Pubmed Aramaki,
A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.
2013,
Pubmed Boiani,
Regulatory networks in embryo-derived pluripotent stem cells.
2005,
Pubmed Chen,
Regulation of male fertility by CFTR and implications in male infertility.
2012,
Pubmed Cohen,
CFTR and Wnt/beta-catenin signaling in lung development.
2008,
Pubmed Collins,
Cystic fibrosis: molecular biology and therapeutic implications.
1992,
Pubmed Dong,
CFTR-regulated MAPK/NF-κB signaling in pulmonary inflammation in thermal inhalation injury.
2015,
Pubmed Dush,
Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak.
1992,
Pubmed Gadue,
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.
2006,
Pubmed Gee,
Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.
2011,
Pubmed Gordon,
Appendix: dialogue on embryonic induction and differentiation waves.
1994,
Pubmed Heasman,
Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.
1994,
Pubmed
,
Xenbase Hodges,
Cystic fibrosis growth retardation is not correlated with loss of Cftr in the intestinal epithelium.
2011,
Pubmed Hoppler,
Studying Wnt signaling in Xenopus.
2008,
Pubmed
,
Xenbase Kemp,
Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.
2005,
Pubmed Kiyonari,
Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability.
2010,
Pubmed Le Henaff,
Genetic deletion of keratin 8 corrects the altered bone formation and osteopenia in a mouse model of cystic fibrosis.
2016,
Pubmed Le Henaff,
Increased NF-κB Activity and Decreased Wnt/β-Catenin Signaling Mediate Reduced Osteoblast Differentiation and Function in ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mice.
2015,
Pubmed Levinson-Dushnik,
Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells.
1997,
Pubmed Lindsley,
Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.
2006,
Pubmed Lu,
CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development.
2012,
Pubmed Lyashenko,
Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation.
2011,
Pubmed McCallum,
Fertility in men with cystic fibrosis: an update on current surgical practices and outcomes.
2000,
Pubmed Moon,
Responses to Wnt signals in vertebrate embryos may involve changes in cell adhesion and cell movement.
1993,
Pubmed
,
Xenbase Moon,
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis.
1993,
Pubmed
,
Xenbase Naito,
Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis.
2006,
Pubmed Nichols,
Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling.
2008,
Pubmed Nusse,
Three decades of Wnts: a personal perspective on how a scientific field developed.
2012,
Pubmed
,
Xenbase Paccou,
Cystic fibrosis-related bone disease.
2013,
Pubmed Pankow,
∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.
2015,
Pubmed Robb,
Gastrula organiser and embryonic patterning in the mouse.
2004,
Pubmed Ruan,
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway.
2014,
Pubmed Sato,
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor.
2004,
Pubmed Schohl,
A role for maternal beta-catenin in early mesoderm induction in Xenopus.
2003,
Pubmed
,
Xenbase Shi,
Heat shock 70-kDa protein 5 (Hspa5) is essential for pronephros formation by mediating retinoic acid signaling.
2015,
Pubmed
,
Xenbase Snouwaert,
An animal model for cystic fibrosis made by gene targeting.
1992,
Pubmed Sun,
Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer.
2014,
Pubmed ten Berge,
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells.
2011,
Pubmed Tizzano,
Cell-specific localization of CFTR mRNA shows developmentally regulated expression in human fetal tissues.
1993,
Pubmed Tsui,
Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.
1985,
Pubmed Umehara,
Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase-3.
2007,
Pubmed van Amerongen,
Towards an integrated view of Wnt signaling in development.
2009,
Pubmed Ying,
The ground state of embryonic stem cell self-renewal.
2008,
Pubmed
