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J Anat
2015 Jun 01;2266:575-95. doi: 10.1111/joa.12303.
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Deconstructing cartilage shape and size into contributions from embryogenesis, metamorphosis, and tadpole and frog growth.
Rose CS, Murawinski D, Horne V.
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Understanding skeletal diversification involves knowing not only how skeletal rudiments are shaped embryonically, but also how skeletal shape changes throughout life. The pharyngeal arch (PA) skeleton of metamorphosing amphibians persists largely as cartilage and undergoes two phases of development (embryogenesis and metamorphosis) and two phases of growth (larval and post-metamorphic). Though embryogenesis and metamorphosis produce species-specific features of PA cartilage shape, the extents to which shape and size change during growth and metamorphosis remain unaddressed. This study uses allometric equations and thin-plate spline, relative warp and elliptic Fourier analyses to describe shape and size trajectories for the ventral PA cartilages of the frog Xenopus laevis in tadpole and frog growth and metamorphosis. Cartilage sizes scale negatively with body size in both growth phases and cartilage shapes scale isometrically or close to it. This implies that most species-specific aspects of cartilage shape arise in embryogenesis and metamorphosis. Contributions from growth are limited to minor changes in lower jaw (LJ) curvature that produce relative gape narrowing and widening in tadpoles and frogs, respectively, and most cartilages becoming relatively thinner. Metamorphosis involves previously unreported decreases in cartilage size as well as changes in cartilage shape. The LJ becomes slightly longer, narrower and more curved, and the adult ceratohyal emerges from deep within the resorbing tadpoleceratohyal. This contrast in shape and size changes suggests a fundamental difference in the underlying cellular pathways. The observation that variation in PA cartilage shape decreases with tadpole growth supports the hypothesis that isometric growth is required for the metamorphic remodeling of PA cartilages. It also supports the existence of shape-regulating mechanisms that are specific to PA cartilages and that resist local adaptation and phenotypic plasticity.
Abzhanov,
Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development.
2004, Pubmed
Abzhanov,
Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development.
2004,
Pubmed Abzhanov,
The calmodulin pathway and evolution of elongated beak morphology in Darwin's finches.
2006,
Pubmed Abzhanov,
Bmp4 and morphological variation of beaks in Darwin's finches.
2004,
Pubmed Berry,
The expression pattern of thyroid hormone response genes in remodeling tadpole tissues defines distinct growth and resorption gene expression programs.
1998,
Pubmed
,
Xenbase Beverdam,
Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: mirror of the past?
2002,
Pubmed Biewener,
Biomechanical consequences of scaling.
2005,
Pubmed Birch,
Skull allometry in the marine toad, Bufo marinus.
1999,
Pubmed Bouvier,
Effects of mechanical loads on surface morphology of the condylar cartilage of the mandible in rats.
1987,
Pubmed Bouvier,
The effect of dietary consistency on gross and histologic morphology in the craniofacial region of young rats.
1984,
Pubmed Carreño,
Aquatic feeding in pipid frogs: the use of suction for prey capture.
2010,
Pubmed
,
Xenbase Cooper,
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions.
2013,
Pubmed Das,
Multiple thyroid hormone-induced muscle growth and death programs during metamorphosis in Xenopus laevis.
2002,
Pubmed
,
Xenbase Depew,
Specification of jaw subdivisions by Dlx genes.
2002,
Pubmed Du Preez,
Reproduction, larval growth, and reproductive development in African clawed frogs (Xenopus laevis) exposed to atrazine.
2008,
Pubmed
,
Xenbase Emerson,
ALLOMETRY AND JUMPING IN FROGS: HELPING THE TWAIN TO MEET.
1978,
Pubmed Ericsson,
Role of cranial neural crest cells in visceral arch muscle positioning and morphogenesis in the Mexican axolotl, Ambystoma mexicanum.
2004,
Pubmed
,
Xenbase Ericsson,
Patterns of spatial and temporal visceral arch muscle development in the Mexican axolotl (Ambystoma mexicanum).
2004,
Pubmed Farnum,
Postnatal bone elongation of the manus versus pes: analysis of the chondrocytic differentiation cascade in Mus musculus and Eptesicus fuscus.
2008,
Pubmed Farnum,
Forelimb versus hindlimb skeletal development in the big brown bat, Eptesicus fuscus: functional divergence is reflected in chondrocytic performance in Autopodial growth plates.
2008,
Pubmed Gendron-Maguire,
Identification of transgenic mice.
1993,
Pubmed Gould,
THE ORIGIN AND FUNCTION OF "BIZARRE" STRUCTURES: ANTLER SIZE AND SKULL SIZE IN THE "IRISH ELK," MEGALOCEROS GIGANTEUS.
1974,
Pubmed Gould,
Allometry and size in ontogeny and phylogeny.
1966,
Pubmed Grammatopoulos,
Homeotic transformation of branchial arch identity after Hoxa2 overexpression.
2000,
Pubmed Haas,
Extreme tadpoles: the morphology of the fossorial megophryid larva, Leptobrachella mjobergi.
2006,
Pubmed Hall,
Postembryonic ontogeny of the spadefoot toad, Scaphiopus intermontanus (Anura: Pelobatidae): skeletal morphology.
1998,
Pubmed Huang,
Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase.
1999,
Pubmed
,
Xenbase Irie,
Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis.
2011,
Pubmed
,
Xenbase Iwata,
SHAPE: a computer program package for quantitative evaluation of biological shapes based on elliptic Fourier descriptors.
2002,
Pubmed Jorgensen,
Effects of temperature regime through premetamorphic ontogeny on shape of the chondrocranium in the American toad, Anaxyrus americanus.
2008,
Pubmed Kerney,
Cartilage on the move: cartilage lineage tracing during tadpole metamorphosis.
2012,
Pubmed
,
Xenbase Kieser,
Comparative morphology of the mandibulodental complex in wild and domestic canids.
1992,
Pubmed Larson,
Ontogeny, phylogeny, and morphology in anuran larvae: morphometric analysis of cranial development and evolution in Rana tadpoles (Anura: Ranidae).
2005,
Pubmed Larson,
Chondrocranial development in larval Rana sylvatica (Anura: Ranidae): morphometric analysis of cranial allometry and ontogenetic shape change.
2002,
Pubmed Mallarino,
Two developmental modules establish 3D beak-shape variation in Darwin's finches.
2011,
Pubmed McFadden,
Effect of controlled dietary consistency and cage environment on the rat mandibular growth.
1986,
Pubmed McMahon,
Size and shape in biology.
1973,
Pubmed Miller,
Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint.
2003,
Pubmed Olsson,
Cranial neural crest cells contribute to connective tissue in cranial muscles in the anuran amphibian, Bombina orientalis.
2001,
Pubmed Pasqualetti,
Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus.
2000,
Pubmed
,
Xenbase Prothero,
Scaling of bodily proportions in adult terrestrial mammals.
1992,
Pubmed Rijli,
A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene.
1993,
Pubmed Rose,
Integrating ecology and developmental biology to explain the timing of frog metamorphosis.
2005,
Pubmed Rose,
Caging, but not air deprivation, slows tadpole growth and development in the amphibian Xenopus laevis.
2014,
Pubmed
,
Xenbase Rose,
Generating, growing and transforming skeletal shape: insights from amphibian pharyngeal arch cartilages.
2009,
Pubmed Ruhin,
Patterning of the hyoid cartilage depends upon signals arising from the ventral foregut endoderm.
2003,
Pubmed Ryerson,
Buccal pumping mechanics of Xenopus laevis tadpoles: effects of biotic and abiotic factors.
2010,
Pubmed
,
Xenbase Sadaghiani,
Neural crest development in the Xenopus laevis embryo, studied by interspecific transplantation and scanning electron microscopy.
1987,
Pubmed
,
Xenbase Schneider,
The cellular and molecular origins of beak morphology.
2003,
Pubmed Schreiber,
Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor.
2001,
Pubmed
,
Xenbase Serrat,
Environmental temperature impact on bone and cartilage growth.
2014,
Pubmed Slater,
Cranial osteogenesis and suture morphology in Xenopus laevis: a unique model system for studying craniofacial development.
2009,
Pubmed
,
Xenbase Tobias,
Rapping, a female receptive call, initiates male-female duets in the South African clawed frog.
1998,
Pubmed
,
Xenbase Tobias,
Development of functional sex differences in the larynx of Xenopus laevis.
1991,
Pubmed
,
Xenbase Trueb,
Skeletal development in Xenopus laevis (Anura: Pipidae).
1992,
Pubmed
,
Xenbase Vandenberg,
Normalized shape and location of perturbed craniofacial structures in the Xenopus tadpole reveal an innate ability to achieve correct morphology.
2012,
Pubmed
,
Xenbase Wassersug,
Aerial respiration facilitates growth in suspension-feeding anuran larvae (Xenopus laevis).
1987,
Pubmed
,
Xenbase Wiens,
Ontogeny of the skeleton of Spea bombifrons (anura: Pelobatidae).
1989,
Pubmed Wilbur,
Ecological Aspects of Amphibian Metamorphosis: Nonnormal distributions of competitive ability reflect selection for facultative metamorphosis.
1973,
Pubmed Wu,
Molecular shaping of the beak.
2004,
Pubmed Wu,
Morphoregulation of avian beaks: comparative mapping of growth zone activities and morphological evolution.
2006,
Pubmed Yamada,
The effect of dietary consistency on bone mass and turnover in the growing rat mandible.
1991,
Pubmed
