Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Cell Cycle
2014 Jan 01;1310:1602-6. doi: 10.4161/cc.28562.
Show Gene links
Show Anatomy links
Meiosis I in Xenopus oocytes is not error-prone despite lacking spindle assembly checkpoint.
Liu D, Shao H, Wang H, Liu XJ.
???displayArticle.abstract???
The spindle assembly checkpoint, SAC, is a surveillance mechanism to control the onset of anaphase during cell division. SAC prevents anaphase initiation until all chromosome pairs have achieved bipolar attachment and aligned at the metaphase plate of the spindle. In doing so, SAC is thought to be the key mechanism to prevent chromosome nondisjunction in mitosis and meiosis. We have recently demonstrated that Xenopus oocyte meiosis lacks SAC control. This prompted the question of whether Xenopus oocyte meiosis is particularly error-prone. In this study, we have karyotyped a total of 313 Xenopus eggs following in vitro oocyte maturation. We found no hyperploid egg, out of 204 metaphase II eggs with countable chromosome spreads. Therefore, chromosome nondisjunction is very rare during Xenopus oocyte meiosis I, despite the lack of SAC.
Angell,
Predivision in human oocytes at meiosis I: a mechanism for trisomy formation in man.
1991, Pubmed
Angell,
Predivision in human oocytes at meiosis I: a mechanism for trisomy formation in man.
1991,
Pubmed Brunet,
Kinetochore fibers are not involved in the formation of the first meiotic spindle in mouse oocytes, but control the exit from the first meiotic M phase.
1999,
Pubmed Burgoyne,
XO monosomy is associated with reduced birthweight and lowered weight gain in the mouse.
1983,
Pubmed Chang,
Interactions of the meiotic spindle with mitotic chromosomes in GV mouse oocytes.
2006,
Pubmed Chiang,
Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes.
2010,
Pubmed Davydenko,
Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I.
2013,
Pubmed Duncan,
Chromosome cohesion decreases in human eggs with advanced maternal age.
2012,
Pubmed Duncan,
Evidence that a defective spindle assembly checkpoint is not the primary cause of maternal age-associated aneuploidy in mouse eggs.
2009,
Pubmed Epstein,
Preimplantation lethality of monosomy for mouse chromosome 19.
1979,
Pubmed Gard,
Microtubule organization, acetylation, and nucleation in Xenopus laevis oocytes: II. A developmental transition in microtubule organization during early diplotene.
1995,
Pubmed
,
Xenbase Hached,
Mps1 at kinetochores is essential for female mouse meiosis I.
2011,
Pubmed Hara,
A cytoplasmic clock with the same period as the division cycle in Xenopus eggs.
1980,
Pubmed
,
Xenbase Hassold,
To err (meiotically) is human: the genesis of human aneuploidy.
2001,
Pubmed Hodges,
SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction.
2005,
Pubmed Hodges,
Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos.
2002,
Pubmed Homer,
Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes.
2005,
Pubmed Houghtaling,
Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle.
2009,
Pubmed
,
Xenbase Kalt,
Observations on early germ cell development and premeiotic ribosomal DNA amplification in Xenopus laevis.
1974,
Pubmed
,
Xenbase Kitajima,
Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes.
2011,
Pubmed Koehler,
Near-human aneuploidy levels in female mice with homeologous chromosomes.
2006,
Pubmed Kudo,
Resolution of chiasmata in oocytes requires separase-mediated proteolysis.
2006,
Pubmed
,
Xenbase Kuliev,
Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing.
2011,
Pubmed Leland,
Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.
2009,
Pubmed LeMaire-Adkins,
Lack of checkpoint control at the metaphase/anaphase transition: a mechanism of meiotic nondisjunction in mammalian females.
1997,
Pubmed Li,
Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis.
2009,
Pubmed Li,
Mitotic forces control a cell-cycle checkpoint.
1995,
Pubmed Lister,
Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2.
2010,
Pubmed Liu,
Oocyte isolation and enucleation.
2006,
Pubmed
,
Xenbase Liu,
Polar body emission.
2012,
Pubmed McGuinness,
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.
2009,
Pubmed Murray,
Dominoes and clocks: the union of two views of the cell cycle.
1989,
Pubmed Musacchio,
The spindle-assembly checkpoint in space and time.
2007,
Pubmed Nagaoka,
Oocyte-specific differences in cell-cycle control create an innate susceptibility to meiotic errors.
2011,
Pubmed Nakamura,
Identification of germline stem cells in the ovary of the teleost medaka.
2010,
Pubmed Ohi,
Nonredundant functions of Kinesin-13s during meiotic spindle assembly.
2007,
Pubmed
,
Xenbase Pines,
Mitosis: a matter of getting rid of the right protein at the right time.
2006,
Pubmed Revenkova,
Oocyte cohesin expression restricted to predictyate stages provides full fertility and prevents aneuploidy.
2010,
Pubmed Rieder,
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores.
1995,
Pubmed Rieder,
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle.
1994,
Pubmed Schuh,
Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes.
2007,
Pubmed Sebestova,
Lack of response to unaligned chromosomes in mammalian female gametes.
2012,
Pubmed Shao,
Aurora B regulates spindle bipolarity in meiosis in vertebrate oocytes.
2012,
Pubmed
,
Xenbase Shao,
Xenopus oocyte meiosis lacks spindle assembly checkpoint control.
2013,
Pubmed
,
Xenbase Sköld,
Assembly pathway of the anastral Drosophila oocyte meiosis I spindle.
2005,
Pubmed Tao,
Deficiency of ovarian ornithine decarboxylase contributes to aging-related egg aneuploidy in mice.
2013,
Pubmed Weaver,
Aneuploidy acts both oncogenically and as a tumor suppressor.
2007,
Pubmed Wignall,
Lateral microtubule bundles promote chromosome alignment during acentrosomal oocyte meiosis.
2009,
Pubmed Yun,
Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes.
2014,
Pubmed Zhang,
Polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion.
2008,
Pubmed
,
Xenbase
