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Bile acids increase the activity of the epithelial Na+ channel.
Wiemuth D, Lefèvre CM, Heidtmann H, Gründer S.
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The epithelial Na(+) channel (ENaC) is a key regulator of Na(+) absorption in various epithelia including the distalnephron and the distalcolon. ENaC is a constitutively active channel, but its activity is modulated by a number of mechanisms. These include proteolytic activation, ubiquitination and cell surface expression, phosphorylation, intracellular Na(+) concentration, and shear stress. ENaC is related to the bile acid-sensitive ion channel (BASIC), a channel that is expressed in the epithelial cells of bile ducts. BASIC is activated by millimolar concentrations of extracellular bile acids. Bile acids are synthesized by the liver and secreted into the duodenum to aid lipolysis. A large fraction of the secreted bile acids is absorbed by the ileum and recirculated into the liver, but a small fraction passes the colon and is excreted. Bile acids can influence the ion transport processes in the intestinal tract including the colon. In this study, we show that various bile acids present in rat bile potently and reversibly increase the activity of rat ENaC expressed in Xenopus oocytes, suggesting that bile acids are natural modulators of ENaC activity.
Awayda,
Regulation of the epithelial Na+ channel by membrane tension.
1998, Pubmed,
Xenbase
Awayda,
Regulation of the epithelial Na+ channel by membrane tension.
1998,
Pubmed
,
Xenbase Balut,
Membrane cholesterol extraction decreases Na+ transport in A6 renal epithelia.
2006,
Pubmed
,
Xenbase Caldwell,
Serine protease activation of near-silent epithelial Na+ channels.
2004,
Pubmed Canessa,
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.
1994,
Pubmed
,
Xenbase Chang,
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1.
1996,
Pubmed Diakov,
Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels.
2008,
Pubmed
,
Xenbase Dopico,
Natural bile acids and synthetic analogues modulate large conductance Ca2+-activated K+ (BKCa) channel activity in smooth muscle cells.
2002,
Pubmed Dürrnagel,
Three homologous subunits form a high affinity peptide-gated ion channel in Hydra.
2010,
Pubmed
,
Xenbase Epple,
Early aldosterone effect in distal colon by transcriptional regulation of ENaC subunits.
2000,
Pubmed Golubovic,
A peptide-gated ion channel from the freshwater polyp Hydra.
2007,
Pubmed Hansson,
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome.
1995,
Pubmed
,
Xenbase Hill,
Endogenously expressed epithelial sodium channel is present in lipid rafts in A6 cells.
2002,
Pubmed Hill,
The epithelial sodium channel (ENaC) traffics to apical membrane in lipid rafts in mouse cortical collecting duct cells.
2007,
Pubmed
,
Xenbase Hofmann,
Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics.
2008,
Pubmed Jasti,
Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH.
2007,
Pubmed Kellenberger,
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.
2002,
Pubmed Krueger,
Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1.
2009,
Pubmed
,
Xenbase Kunzelmann,
Electrolyte transport in the mammalian colon: mechanisms and implications for disease.
2002,
Pubmed Lapré,
Diet-induced increase of colonic bile acids stimulates lytic activity of fecal water and proliferation of colonic cells.
1992,
Pubmed Lefèvre,
Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).
2014,
Pubmed Lima,
The effect of bile acid on the activation of amiloride-sensitive sodium channels in frog skin.
1996,
Pubmed Lingueglia,
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel.
1995,
Pubmed
,
Xenbase Mauricio,
Deoxycholic acid (DOC) affects the transport properties of distal colon.
2000,
Pubmed Mekhjian,
Perfusion of the canine colon with unconjugated bile acids. Effect on water and electrolyte transport, morphology, and bile acid absorption.
1970,
Pubmed Mekjian,
Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man.
1971,
Pubmed Rossier,
Epithelial sodium channel: mendelian versus essential hypertension.
2008,
Pubmed Rossier,
Epithelial sodium channels.
1994,
Pubmed Sakakura,
Simultaneous determination of bile acids in rat bile and serum by high-performance liquid chromatography.
1993,
Pubmed Shimkets,
Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel.
1994,
Pubmed Wiemuth,
The pharmacological profile of brain liver intestine Na+ channel: inhibition by diarylamidines and activation by fenamates.
2011,
Pubmed
,
Xenbase Wiemuth,
BASIC--a bile acid-sensitive ion channel highly expressed in bile ducts.
2012,
Pubmed Wiemuth,
Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid.
2013,
Pubmed Wiemuth,
A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC).
2010,
Pubmed
,
Xenbase
