Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Members of the leucine zipper putative tumor suppressor (LZTS) family play crucial roles in transcription modulation and cell cycle control. We previously demonstrated that LZTS2 functions as a novel β-catenin-interacting protein and represses β-catenin-mediated transcription on T-cell factor/lymphoid enhancing factor. Here, we investigate the biological role of LZTS2 using newly established Lzts2 KO mice. Homozygosity for loss-of-function of the Lzts2-targeted allele resulted in severe kidney and urinary tract developmental defects, including renal/ureteral duplication, hydroureter, and hydronephrosis, which were visible prenatally. Altered ureteric bud outgrowth was identified in Lzts2 null embryos. Further analysis indicated that β-catenin subcellular localization was altered in fibroblasts isolated from Lzts2 null embryos. In addition, Wnt growth factor-induced β-catenin-mediated transcriptional activity was increased in Lzts2 null fibroblasts, suggesting a direct role for Lzts2 in the Wnt signaling pathway. These data demonstrate a critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of β-catenin-mediated nephrogenesis.
Basson,
Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.
2006, Pubmed
Basson,
Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.
2006,
Pubmed Beliakoff,
The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.
2008,
Pubmed Bridgewater,
Canonical WNT/beta-catenin signaling is required for ureteric branching.
2008,
Pubmed Cabeza-Arvelaiz,
LAPSER1: a novel candidate tumor suppressor gene from 10q24.3.
2001,
Pubmed Chen,
Genetic and developmental basis for urinary tract obstruction.
2009,
Pubmed Costantini,
GDNF/Ret signaling and the development of the kidney.
2006,
Pubmed Dressler,
Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities.
1993,
Pubmed Gray,
Mouse brain organization revealed through direct genome-scale TF expression analysis.
2004,
Pubmed Hyun Hwa Cho,
Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells.
2008,
Pubmed Ichikawa,
Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT.
2002,
Pubmed Iglesias,
Canonical WNT signaling during kidney development.
2007,
Pubmed Kerecuk,
Renal tract malformations: perspectives for nephrologists.
2008,
Pubmed Kobayashi,
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development.
2005,
Pubmed
,
Xenbase Lakso,
Targeted oncogene activation by site-specific recombination in transgenic mice.
1992,
Pubmed Li,
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
1997,
Pubmed Mahoney,
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.
2006,
Pubmed Marose,
Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state.
2008,
Pubmed
,
Xenbase Moore,
Renal and neuronal abnormalities in mice lacking GDNF.
1996,
Pubmed Pachnis,
Expression of the c-ret proto-oncogene during mouse embryogenesis.
1993,
Pubmed Park,
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development.
2007,
Pubmed Peng,
A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.
2010,
Pubmed Peters,
Animal models of fetal renal disease.
2001,
Pubmed Pichel,
Defects in enteric innervation and kidney development in mice lacking GDNF.
1996,
Pubmed Qian,
Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.
2005,
Pubmed Rodríguez,
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP.
2000,
Pubmed Rosenthal,
The GDNF protein family: gene ablation studies reveal what they really do and how.
1999,
Pubmed Saadi-Kheddouci,
Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene.
2001,
Pubmed Sainio,
Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium.
1997,
Pubmed Saxén,
Early organogenesis of the kidney.
1987,
Pubmed Schmeisser,
Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses.
2009,
Pubmed Sharma,
hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci.
2003,
Pubmed Sudo,
LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin.
2007,
Pubmed Sudo,
LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing.
2008,
Pubmed Teufel,
In silico characterization of LZTS3, a potential tumor suppressor.
2005,
Pubmed Thyssen,
LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.
2006,
Pubmed Vecchione,
Fez1/lzts1 alterations in gastric carcinoma.
2001,
Pubmed Vecchione,
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
2007,
Pubmed Verras,
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells.
2004,
Pubmed
