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Planar cell polarity (PCP) is a property of epithelial tissues where cellular structures coordinately orient along a two-dimensional plane lying orthogonal to the axis of apical-basal polarity. PCP is particularly striking in tissues where multiciliate cells generate a directed fluid flow, as seen, for example, in the ciliated epithelia lining the respiratory airways or the ventricles of the brain. To produce directed flow, ciliated cells orient along a common planar axis in a direction set by tissue patterning, but how this is achieved in any ciliated epithelium is unknown. Here, we show that the planar orientation of Xenopus multiciliate cells is disrupted when components in the PCP-signaling pathway are altered non-cell-autonomously. We also show that wild-type ciliated cells located at a mutant clone border reorient toward cells with low Vangl2 or high Frizzled activity and away from those with high Vangl2 activity. These results indicate that the PCP pathway provides directional non-cell-autonomous cues to orient ciliated cells as they differentiate, thus playing a critical role in establishing directed ciliary flow.
Adler,
Planar signaling and morphogenesis in Drosophila.
2002, Pubmed
Adler,
Planar signaling and morphogenesis in Drosophila.
2002,
Pubmed Amonlirdviman,
Mathematical modeling of planar cell polarity to understand domineering nonautonomy.
2005,
Pubmed Boutros,
Dishevelled: at the crossroads of divergent intracellular signaling pathways.
1999,
Pubmed
,
Xenbase Chen,
Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling.
2008,
Pubmed Davidson,
Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin alpha(5)beta(1), fibronectin, and tissue geometry.
2002,
Pubmed
,
Xenbase Goto,
The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus.
2002,
Pubmed
,
Xenbase Heisenberg,
Wnt signalling: a moving picture emerges from van gogh.
2002,
Pubmed Lawrence,
Planar cell polarity: one or two pathways?
2007,
Pubmed Marshall,
Cilia orientation and the fluid mechanics of development.
2008,
Pubmed Mitchell,
A positive feedback mechanism governs the polarity and motion of motile cilia.
2007,
Pubmed
,
Xenbase Park,
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling.
2006,
Pubmed
,
Xenbase Park,
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells.
2008,
Pubmed
,
Xenbase Rasmussen,
Regulation of eye development by frizzled signaling in Xenopus.
2001,
Pubmed
,
Xenbase Ross,
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.
2005,
Pubmed Seifert,
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility.
2007,
Pubmed Strutt,
Differential stability of flamingo protein complexes underlies the establishment of planar polarity.
2008,
Pubmed Strutt,
The planar polarity pathway.
2008,
Pubmed Strutt,
Differential activities of the core planar polarity proteins during Drosophila wing patterning.
2007,
Pubmed Stubbs,
Radial intercalation of ciliated cells during Xenopus skin development.
2006,
Pubmed
,
Xenbase Taylor,
Van Gogh: a new Drosophila tissue polarity gene.
1998,
Pubmed Vinson,
Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila.
,
Pubmed Wallingford,
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity.
2005,
Pubmed Wang,
The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.
2006,
Pubmed Wang,
Tissue/planar cell polarity in vertebrates: new insights and new questions.
2007,
Pubmed Wu,
The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling.
2008,
Pubmed Zallen,
Planar polarity and tissue morphogenesis.
2007,
Pubmed
