Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Synapsin IIa accelerates functional development of neuromuscular synapses.
Schaeffer E, Alder J, Greengard P, Poo MM.
???displayArticle.abstract???
We have investigated the possible involvement of the synaptic vesicle protein synapsin IIa in synapse development. Synapsin IIa was introduced into Xenopus embryonic spinal neurons by early blastomere injection, and nerve-muscle cultures were prepared. Synaptic currents were measured by comparing synapses in which the presynaptic neuron either contained [syn IIa (+)] or lacked (control) exogenous synapsin IIa. Syn IIa (+) synapses had a 3.6-fold increase in the frequency and a 2.1-fold increase in the amplitude of spontaneous synaptic currents, compared to controls, after 2 days in culture. Synapsin IIa also increased the amplitude of evoked synaptic currents by 2.3-fold in 2-day cultures. The evoked synaptic current amplitudes of syn IIa (+) synapses had a lower coefficient of variation indicating a more stable evoked response. These enhanced synaptic activities were independent of the presence or absence of the protein in the postsynaptic muscle cell. The findings indicate a role for synapsin IIa in synapse maturation.
Anderson,
Effects of innervation on the distribution of acetylcholine receptors on cultured muscle cells.
1977, Pubmed,
Xenbase
Anderson,
Effects of innervation on the distribution of acetylcholine receptors on cultured muscle cells.
1977,
Pubmed
,
Xenbase Buchanan,
Studies of nerve-muscle interactions in Xenopus cell culture: fine structure of early functional contacts.
1989,
Pubmed
,
Xenbase DeGennaro,
Neuron-specific phosphoproteins as models for neuronal gene expression.
1983,
Pubmed Evers,
Studies of nerve-muscle interactions in Xenopus cell culture: analysis of early synaptic currents.
1989,
Pubmed
,
Xenbase Fu,
ATP potentiates spontaneous transmitter release at developing neuromuscular synapses.
1991,
Pubmed
,
Xenbase Greengard,
Synaptic vesicle phosphoproteins and regulation of synaptic function.
1993,
Pubmed Hackett,
Synapsin I injected presynaptically into goldfish mauthner axons reduces quantal synaptic transmission.
1990,
Pubmed Hall,
Synaptic structure and development: the neuromuscular junction.
1993,
Pubmed Han,
Induction of formation of presynaptic terminals in neuroblastoma cells by synapsin IIb.
1991,
Pubmed Kidokoro,
Two types of miniature endplate potentials in Xenopus nerve-muscle cultures.
1984,
Pubmed
,
Xenbase Levitt,
Emergence of cyclic guanosine 3':5'-monophosphate-dependent protein kinase immunoreactivity in developing rhesus monkey cerebellum: correlative immunocytochemical and electron microscopic analysis.
1984,
Pubmed Lin,
Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse.
1990,
Pubmed Llinás,
Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.
1985,
Pubmed Llinás,
Regulation by synapsin I and Ca(2+)-calmodulin-dependent protein kinase II of the transmitter release in squid giant synapse.
1991,
Pubmed Lohmann,
Ontogeny of synaptic phosphoproteins in brain.
1978,
Pubmed Lu,
Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses.
1992,
Pubmed
,
Xenbase Mason,
Axon development in mouse cerebellum: embryonic axon forms and expression of synapsin I.
1986,
Pubmed Nastuk,
Agrin and the molecular choreography of synapse formation.
1993,
Pubmed Nichols,
Synapsin I regulates glutamate release from rat brain synaptosomes.
1992,
Pubmed Sanes,
In vitro analysis of position- and lineage-dependent selectivity in the formation of neuromuscular synapses.
1989,
Pubmed
,
Xenbase Siow,
Synapsin IIa: expression in insect cells, purification, and characterization.
1992,
Pubmed Spitzer,
The development of the action potential mechanism of amphibian neurons isolated in culture.
1976,
Pubmed
,
Xenbase Südhof,
Proteins of synaptic vesicles involved in exocytosis and membrane recycling.
1991,
Pubmed Südhof,
Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.
1989,
Pubmed Trimble,
Cellular and molecular biology of the presynaptic nerve terminal.
1991,
Pubmed Valtorta,
Structure and function of the synapsins.
1992,
Pubmed Zucker,
Short-term synaptic plasticity.
1989,
Pubmed
