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Summary ExpressionExpr. PhenotypesPheno. Gene Literature (0)Lit. (0) GO Terms (22)GO (22) Nucleotides (107)Nucl. (107) Proteins (55)Prot. (55) Interactants (89)Interact. (89) Wiki
XB-GENEPAGE-987087
???displayGene.symbol???:
 dock8

???displayGene.name???: 
dedicator of cytokinesis 8

???displayGene.synonyms???
( Nomenclature history )

???displayGene.geneFunction???
PH domain-containing protein

AI Protein Function :
dock8 is a DOCK family guanine nucleotide‑exchange factor that activates Cdc42 and Rac1 to control actin cytoskeleton dynamics and cell migration. The protein functions as a cytoplasmic signaling molec...[+]


InterPro :
DHR-1 domain, C2 Dock-C, DOCK C/D N, DOCK, [+]

???displayGene.geneInteractants???
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Diseases: 


Disease Ontology:
autosomal dominant intellectual developmental disorder [+]

MIM:
HYPER-IgE SYNDROME 2, AUTOSOMAL RECESSIVE, WITH RECURRENT INFECTIONS; HIES2 [+]

External Links:
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???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


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