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Summary Expression Expr. PhenotypesPheno. Gene Literature (2)Lit. (2) GO Terms (11)GO (11) Nucleotides (163)Nucl. (163) Proteins (63)Prot. (63) Interactants (489)Interact. (489) Wiki
XB-GENEPAGE-5998209
???displayGene.symbol???:
 plekhg4

???displayGene.name???: 
pleckstrin homology and RhoGEF domain containing G4

???displayGene.synonyms???
arhgef44 , prtphn1 , sca4 ( Nomenclature history )

???displayGene.geneFunction???
Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains

AI Protein Function :
plekhg4 encodes a Rho‑guanine nucleotide exchange factor that activates Cdc42, thereby regulating actin cytoskeleton dynamics and neurite outgrowth; the protein functions as a signaling molecule locali...[+]


InterPro :
DH-domain, PH domain, DBL dom sf, CRAL-TRIO dom, [+]

???displayGene.geneInteractants???
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Diseases: 


Disease Ontology:
spinocerebellar ataxia 4 [+]

MIM:
SPINOCEREBELLAR ATAXIA 31; SCA31 [+]

External Links:
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???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


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