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Summary Expression Expr. PhenotypesPheno. Gene Literature (16)Lit. (16) GO Terms (60)GO (60) Nucleotides (137)Nucl. (137) Proteins (37)Prot. (37) Interactants (213)Interact. (213) Wiki
XB-GENEPAGE-478671
???displayGene.symbol???:
 irs1

???displayGene.name???: 
insulin receptor substrate 1

???displayGene.synonyms???
irs-1 , LOC108718134 ( Nomenclature history )

???displayGene.geneFunction???
exo-a-sialidase

AI Protein Function :
irs1 encodes a signaling adaptor protein that links insulin and IGF receptors to downstream PI3K‑AKT and MAPK pathways, influencing glucose metabolism, cell growth and differentiation; the protein loca...[+]


InterPro :
IRS PTB, PH domain, PH-like dom sf, IRS

???displayGene.geneInteractants???
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Diseases: 


Disease Ontology:
type 2 diabetes mellitus

MIM:
TYPE 2 DIABETES MELLITUS; T2D

External Links:
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???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


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