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Summary Expression Expr. PhenotypesPheno. Gene Literature (10)Lit. (10) GO Terms (32)GO (32) Nucleotides (109)Nucl. (109) Proteins (39)Prot. (39) Interactants (81)Interact. (81) Wiki
XB-GENEPAGE-1012023
???displayGene.symbol???:
 lrrc8a

???displayGene.name???: 
leucine rich repeat containing 8 VRAC subunit A

???displayGene.synonyms???
agm5 , lrrc8 , swell1 ( Nomenclature history )

???displayGene.geneFunction???
Leucine-rich repeat (LRR) protein associated with apoptosis in muscle tissue

AI Protein Function :
lrrc8a encodes a plasma‑membrane component of the volume‑regulated anion channel that conducts chloride and organic osmolytes to restore cell volume after swelling; it is required for osmotic stress‑in...[+]


InterPro :
Leu-rich rpt, Leu-rich rpt typical-subtyp, LRR dom sf, LRR domain-containing, [+]

???displayGene.geneInteractants???
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Diseases: 


Disease Ontology:
agammaglobulinemia [+]

MIM:
AGAMMAGLOBULINEMIA 1, AUTOSOMAL RECESSIVE; AGM1 [+]

External Links:
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???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


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